Buried beneath reality show headlines, the NYT breathlessly informs us, “Scientists Talk Privately” about something. To wit, a group at Harvard has a secret meeting to plan to “create” an entire set of human chromosomes. Could this really be it–an Artificial Person? Without (gasp!) biological parents?
Like a rather bad Heinlein novel, there are enough contradictions to go around.
First of all, what’s so unique about making a human genome–something trillions of our own body cells do every day? The NYT informs us, the scientists will “use chemicals to manufacture all the DNA.” Mm-hm. So my own cells are made of what, if not chemicals? Cosmic ray particles, maybe?
What we call “chemicals” presumably means bulk processed petrochemical products stored in 1-kilo bottles obtained from Sigma-Aldrich or Thermo-Fisher. And “manufacture” means a concrete-slab factory, where mostly male persons “fabricate” things, as opposed to a bit of meat within a female that uses its own DNA copying enzymes.
But suppose, continues NYT, we could “use a synthetic genome to create human beings without biological parents?”
Project leader George Church (who started out as a bacterial molecular biologist) assures us we’ve got it wrong. “They’re painting a picture which I don’t think represents the project,” Church observes. The project is “not aimed at creating people, just cells.” Again, this claim represents a surprisingly parochial view of what constitutes the “natural” human reproductive process. We can argue endlessly over whether a fertilized egg or embryo constitutes a human being, but there can be no doubt that most of our bodies at some point developed from a single cell that became a few more cells.
The technology exists to replace the nucleus of an egg cell with a new nucleus. Could a “synthetic” set of human chromosomes replace the chromosomes of an egg cell? What about a skin cell transformed into an egg, something also near possibility?
Of course, no article about artificial human life is going to get away without mentioning Einstein. The crowning awful possibility: “Would it be O.K., for example, to sequence and then synthesize Einstein’s genome? If so how many Einstein genomes should be made and installed in cells, and who would get to make them?”
Please–Enough already Einstein. Myself, I’d rather recreate Mileva Marić, the physicist whom Einstein got pregnant and married, and who probably co-created his most famous works.
So why create a synthetic human genome? We don’t know, given the “secret” nature of the Harvard meeting, but let’s give them a break and assume they just want a more efficient way to “construct” a genome out of various parts and see what it does in a cell. Cell culture is a lot more efficient than running after mini-humans (mice), as some of my students can attest. Nevertheless, we approach ever nearer the day when any skin cell could become a human.
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